DEVELOPMENT OF CUO NANOPARTICLE-BASED ELECTROCHEMICAL SENSORS FOR THE DETECTION OF HEMATOLOGICAL CANCER BIOMARKERS

Abstract

The design of nanomaterial-based electrochemical sensors has been the subject of increasing interest in biomedical research owing to their high sensitivity and fast responses to disease-related biomarkers. In this work, CuO nanoparticles were fabricated and studied for their possible use in electrochemical sensing of hematological cancer-related biomarkers in human blood samples. The fabricated nanoparticles were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX/EDS), X-ray Diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) in order to determine their surface morphology, elemental composition, and characteristic chemical functional groups, respectively. After characterization, CuO nanoparticles were used in the fabrication of a nanomaterial-based electrochemical sensor. The electrochemical performance of the fabricated sensor was studied by applying blood samples collected from healthy subjects and patients suffering from hematological cancers. The sensor output signal was analyzed to determine its capability to differentiate between cancer-related and healthy electrochemical signals. The results of this study are aimed at evaluating the potential of CuO nanoparticles as nanomaterials for electrochemical sensing. This study may lay the ground work for the development of low-cost nanomaterial-based sensing systems for the analysis of hematological cancer biomarkers.